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Treatment Options by Stage

Stage I and Stage II Oropharyngeal Cancer

Treatment of stage I and stage II oropharyngeal cancer may include the following:

Check the list of NCI-supported cancer clinical trials that are now accepting patients with stage I oropharyngeal cancer and stage II oropharyngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI website.

Stage III and Stage IV Oropharyngeal Cancer

Treatment of stage III oropharyngeal cancer and stage IV oropharyngeal cancer may include the following:

  • For patients with locally advanced cancer, surgery followed by radiation therapy. Chemotherapy also may be given at the same time as radiation therapy.
  • Radiation therapy alone for patients who cannot have chemotherapy.
  • Chemotherapy given at the same time as radiation therapy.
  • Chemotherapy followed by radiation therapy given at the same time as more chemotherapy.
  • A clinical trial of chemotherapy followed by surgery or radiation therapy.
  • A clinical trial of targeted therapy (nivolumab) with chemotherapy given at the same time as radiation therapy in patients with advanced HPV -positive oropharyngeal cancer.
  • A clinical trial of radiation therapy with or without chemotherapy.
  • A clinical trial of transoral surgery followed by standard - or low-dose radiation therapy with or without chemotherapy in patients with HPV-positive oropharyngeal cancer.

Check the list of NCI-supported cancer clinical trials that are now accepting patients with stage III oropharyngeal cancer and stage IV oropharyngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI website.

Recurrent Oropharyngeal Cancer

Treatment of recurrent oropharyngeal cancer may include the following:

Check the list of NCI-supported cancer clinical trials that are now accepting patients with recurrent oropharyngeal cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI website.


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