In myeloproliferative neoplasms, too many blood stem cells become one or more types of blood cells. The neoplasms usually get worse slowly as the number of extra blood cells increases.
There are 6 types of chronic myeloproliferative neoplasms.
The type of myeloproliferative neoplasm is based on whether too many red blood cells, white blood cells, or platelets are being made. Sometimes the body will make too many of more than one type of blood cell, but usually one type of blood cell is affected more than the others are. Chronic myeloproliferative neoplasms
include the following 6 types:
These types are described below. Chronic myeloproliferative neoplasms sometimes become acute leukemia, in which too many abnormal
white blood cells are made.
Tests that examine the blood and bone marrow are used to detect (find) and diagnose chronic myeloproliferative neoplasms.
The following tests and procedures may be used:
and history: An exam of the body to check general signs
of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient’s health habits and past illnesses and treatments will also be taken.
Blood chemistry studies: A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs
and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease.
Cytogenetic analysis: A test in which cells in a sample of blood or bone marrow are viewed under a microscope to look for certain changes in the chromosomes. Certain diseases or disorders
may be diagnosed
or ruled out based on the chromosomal changes.
test: A laboratory test
done on a bone marrow or blood sample to check for mutations in JAK2, MPL, or CALR genes. A JAK2 gene mutation is often found in patients with polycythemia vera, essential thrombocythemia, or primary myelofibrosis. MPL or CALR gene mutations are found in patients with essential thrombocythemia or primary myelofibrosis.
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